Summary of Clinical Trials with RP101 PDF Print E-mail

Several clinical studies have been conducted with RP101 tablets in oncology. In a pilot phase 1 study, 31 patients with various tumor types were treated with multiple chemotherapeutic agents and RP101. In this study with 5 tumor entities (lung, breast, ovary, pancreas) it was shown that RP101 could be combined with various cytotoxic drugs: as mono-chemotherapy-regime vinorelbin, gemcitabine, docetaxel, epirubicin; as poly-chemotherapy-regime carboplatin + gemcitabin + vinorelbine, doxorubicin + endoxan + vincristine, carboplatin + vinorelbine, carboplatin + paclitaxel, carboplatin + docetaxel, carboplatin + etoposide, carboplatin + irinotecane, cisplatin + gemcitabine, epirubicin + endoxan.

This study was extended to treat 13 patients with advanced pancreatic carcinoma (Stage III and IV). In an open label study, patients received gemcitabine + cisplatin + RP101 (500 mg/day) in 5-day cycles. A dose ranging study of RP101 and gemcitabine was completed at three sites in Germany. In this study, 22 patients were treated with a fixed dose of gemcitabine (1000 mg/m2 for 3 days) and varying doses of RP101 (500-1000 mg/day) for 12 days of a 28 day cycle.

Food effect studies with healthy volunteers showed that it is profitable not to eat immediately before taking RP101 tablets.

 

 Clinical Studies - Overview

Clinical State

Year

No. Of Patients

Indication

Region

Type

Pilot /
Phase I

2001-2003

30

Multiple Tumors

Germany

Initial Pilot Study /
First in Man

Phase IIa

2003-2004

13

Pancreatic Cancer

Germany

Extended Study /
Proof of Concept

Phase IIb

2004-2006

22

Pancreatic Cancer

Germany

Dose Finding Study

Phase I

2007-2008

18

-

USA

Food Effect Study
Healthy volunteers

Phase IIb

2007-2010

167
(orig. 153)

Pancreatic Cancer

USA, Europe, South America (50 sites)

Double blind placebo controlled; endpoint = overall survival